von Willebrand Factor

A high-molecular-weight plasma protein, produced by endothelial cells and megakaryocytes, that is part of the factor VIII/von Willebrand factor complex. The von Willebrand factor has receptors for collagen, platelets, and ristocetin activity as well as the immunologically distinct antigenic determinants. It functions in adhesion of platelets to collagen and hemostatic plug formation. The prolonged bleeding time in VON WILLEBRAND DISEASES is due to the deficiency of this factor.

Also Known As:

Factor VIIIR-Ag; Factor VIIIR-RCo; Plasma Factor VIII Complex; Ristocetin Cofactor; Ristocetin-Willebrand Factor; von Willebrand Protein; Factor VIII Related Antigen; Factor VIIIR Ag; Factor VIIIR RCo; Ristocetin Willebrand Factor; Factor VIII-Related Antigen

Amino Acids, Peptides, and Proteins: 1
- Proteins: 496323
  - Blood Proteins: 12679
    - Blood Coagulation Factors: 5500
      - von Willebrand Factor: 6815
Biological Factors: 2560
- Blood Coagulation Factors: 5500
  - von Willebrand Factor: 6815

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Disease

Drug/Important Bio-Agent (IBA)